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Publications

MANUSCRIPTS

2023-2024

  1. Sharma P. Breier D and Peer D.(2024) Immunogenic Amines on Lipid Nanoparticles. Nat Biomed Eng. PDF

  2. Lo´pez-Camacho C,  Gabriel Alameh M, Peer D, Culis P. (2024) RNA Vaccines for Prevalent and Newly Emerging Diseases. Frontires In Immunology. PDF
  3. Gao H, Li S,  Lan Z, Pan D,  Naidu G.S, Peer  D,  Ye C, Chen H, Ma M ,Liu Z, Santos H.A. (2024) Comparative Optimization of Polysaccharide-Based Nanoformulations for Cardiac RNAi Therapy. Nature Communications. 15:5398, 1-19. PDF
  4. Anchordoquy T,  Artzi N, Balyasnikova U.V, Barenholz Y,  La-Beck N.M, Brenner J.B,  Chan W.C.W, Decuzzi P, Exner A.A, Gabizon A,  Godin B,  Lai S.K,  Lammers T,  Mitchell M.J,  Moghimi S.M,  Muzykantov V.R, Peer D, Nguyen J,  Popovtzer R,  Ricco M, Serkova N.J, Singh R, Schroeder A,  Schwendeman A.A, Straehla J.P,  Teesalu T, Tilden S, and  Simberg D. (2024) Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS Nano. PDF
  5. Guo SK, Liu CX, Xu YF, Wang X, Nan F, Huang Y, Li S, Nan S, Li L, Kon E, Li C, Wei MY, Su R, Wei J, Peng S, Ad-El N, Liu J, Peer D, Chen T, Yang L, Chen LL. (2024) Therapeutic Application of Circular RNA Aptamers in a Mouse Model of Psoriasis. Nature Biotechnol. PDF 
  6. Bin Kanner Y, Teng Q.X, Ganoth A, Peer D, Wang J.Q, Chen Z.H, Tsfadia Y. (2023) Cytotoxicity and Reversal Effect of Sertraline, Fluoxetine, and Citalopram on MRP1- and MRP7-Mediated MDR. Front. Pharmacol. PDF
  7. Deprez J, Verbeke R, Meulewaeter S, Aernout I, Dewitte H, Decruy T, Coudenys J, Van Duyse J, Van Isterdael G, Peer D, Van der Meel R, De Smedt SC, Jacques P, Elewaut D, Lentacker I. (2023)  Transport by Circulating Myeloid Cells Drives Liposomal Accumulation in Inflamed Synovium. Nat Nanotechnol. 18(11):1341-1350. PDF
  8. Elia U, Kon E, Peer D.(2023) Nat Biotechnol. CRISPR Editing in the Lung with Novel Lipids.  41(10):1387-1388. PDF
  9. Peer D. (2023) Drug Delivery Research and Much More: an Interview with Dan Peer.  Nanomedicine (Lond).  PDF
  10. Tarab-Ravski D, Hazan-Halevy I, Goldsmith M, Stotsky-Oterin L, Breier D, Naidu GS, Aitha A, Diesendruck Y, Ng BD, Barsheshet H, Berger T, Vaxman I, Raanani P, Peer D. (2023) Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted Lipid Nanoparticles. Adv Sci (Weinh) 12:e2301377. PDF
  11. Naidu Gonna S, Seok–Beom Y, Ramishetti S, Rampado R, Sharma P, Ezra A, Goldsmith M, Hazan–Halevy I, Chatterjee S, Aitha A , Peer D. (2023) A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery. Adv. Sci. 2301929. PDF
  12. Granot-Matok Y,  Ezra A, Ramishetti S, Sharm P, Naidu Gonna S, Benhar I, Peer D. (2023) Lipid Nanoparticles-Loaded with Toxin mRNA Represents a New Strategy for the Treatment of Solid Tumors. Theranostic 13(11): 3467-3478. PDF
  13. Chatterjee S, Naidu GS, Hazan-Halevy I, Grobe H, Ezra A, Sharma P, Goldsmith M, Ramishetti S, Sprinzak D, Zaidel-Bar R, Peer D. (2023) Therapeutic Gene Silencing of CKAP5 Leads to Lethality in Genetically Unstable Cancer Cells. Sci. Adv. 5:9(14). PDF
  14. Kon E, Levy Y, Elia U, Cohen H, Hazan-Halevy I, Aftalion M, Ezra A, Bar-Haim E, Naidu GS, Diesendruck Y, Rotem S, Ad-El N, Goldsmith M, Mamroud E, Peer D, Cohen O.(2023) A Single-Dose F1-Based mRNA-LNP Vaccine Provides Protection Against the Lethal Plague Bacterium. Sci Adv. 9(10):1036. PD, 1-O. 

2021-2022

  1. Karpov O, Lahav M,  Wolach O, Raanani P, Peer D, Kaplan T and Uziel O (2022) Identification of Cancer Cells in the Human Body by Anti Telomerase Peptide Antibody: Towards the Isolation of Circulating Tumor Cells. Int. J. Mol. Sci., 23, 12872, 1-14. PDF
  2. Bogaert B., Sauvage F., Guagliardo R., Muntean C., Nguyen V.P.,  ottie E., Wels M., Minnaert A.K., DeRycke R., Yang Q., Peer D., Sanders N., Remaut K., Paulus Y.M., Stove C., De Smedt S.C., Raemdonck K. (2022) A Lipid Nanoparticle Platform for mRNA Delivery Through Repurposing of Cationic Amphiphilic Drugs. J. Control Release  S0168-3659.
  3. Poley M., Mora-Raimundo P., Shammai Y., Maya Kaduri, Koren L.,  Adir O., Jeny Shklover,  Shainsky-Roitman J.,  Ramishetti S.,  Man F., De Rosales R., Zinger A., Peer D., Ben-Aharon I., and Schroeder A. (2022). Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Cancer Treatment and Fertility. ACS Nano. PDF
  4. Seok–Beom Y, Ramishetti S, Goldsmith M, Diesendruck Y, Hazan–Halevy I, Chatterjee S,  Naidu Gonna S, Ezra A, Peer D. (2022) Dual–Targeted Lipid Nanotherapeutic Boost for Chemo–Immunotherapy of Cancer. Advanced Materials 2106350:1-13. PDF
  5. Cohen-Erner M,*  Khandadash R,* Hof R, Shalev O,  Antebi A,  Cyjon A,  Kanakov D, Nyska A,  Goss G, Hilton J, and  Peer D (2021) Fe3O4 Nanoparticles and Paraffin Wax as Phase Change Materials Embedded in Polymer Matrixes for Temperature-Controlled Magnetic Hyperthermia. ACS Applied Nano Material. PDF
  6. Kampel L, Goldsmith M, Ramishetti S, Veiga V, Rosenblum D, Gutkin A, Chatterjee S, Penn M, Lerman G, Peer D, Muhanna N. (2021) Therapeutic Inhibitory RNA in Head and Neck Cancer via Functional Targeted Lipid Nanoparticles. Journal of Controlled Release 337:378-389. PDF
  7. Dammes N, Goldsmith M, Ramishetti S, Dearling J. L .J, Veiga N, Packard A. B and Peer D (2021) Conformation-Sensitive Targeting of Lipid Nanoparticles for RNA Therapeutics. Nature Nanotechology. 16(9):1030-1038. PDF
  8. Elia U, Rotem S, Bar-Haim E, Ramishetti S, Naidu GS, Gur D, Aftalion M, Israeli M, Bercovich-Kinori A, Alcalay R, Makdasi E, Chitlaru T, Rosenfeld R, Israely T, Melamed S, Abutbul Ionita I, Danino D, Peer D, Cohen O. (2021) Lipid Nanoparticle RBD-hFc mRNA Vaccine Protects hACE2 Transgenic Mice Against a Lethal SARS-CoV-2 Infection. Nano Let. 21(11):4774-4779. PDF 
  9. Smriti Singh M, Ramishetti S, Landesman‐Milo D, Goldsmith M, Chatterjee S, Palakuri R, Peer D. (2021) Therapeutic Gene Silencing Using Targeted Lipid Nanoparticles in Metastatic Ovarian Cancer. Small 17(19):e2100287. PDF
  10. Aday S, Hazan-Halevy I, Chamorro-Jorganes A, Anwar M, Goldsmith M, Beazley-Long N, Sahoo S, Dogra N, Sweaad W, Catapano F, Ozaki-Tan S, Angelini GD, Madeddu P, Benest AV, Peer D, Emanueli C. (2021) Bioinspired Artificial Exosomes Based on Lipid Nanoparticles Carrying let-7b-5p Promote Angiogenesis in vitro and in vivo. Molecular Therapy.29(7):2239-2252. PDF
  11. Elia U, Ramishetti S, Rosenfeld R, Dammes N, Bar-Haim E, Somu Naidu G, Makdasi E, Yahalom-Ronen Y,  Tamir H, Paran N, Cohen O, Peer D. (2021) Design of SARS-CoV2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles. ACS Nano.15(6):9627-9637. PDF

  2019-2020

  1. Rosenblum D, Gutkin  A,  Kedmi K, Ramishetti  S,  Veiga N,  Jacobi A.M, Schubert M.S,  Friedmann- Morvinski D,  Cohen Z.R, Behlke M.A, Liberman J,  Peer D. (2020) CRISPR-Cas9 Genome Editing Using Targeted Lipid Nanoparticles for Cancer Therapy. Science Advances 6(47):eabc9450. PDF 
  2. Uebbing L, Ziller A, Siewert C,  Schroer M.A,  Blanchet C.E, Svergun D.I, Ramishetti S, Peer D, Sahin U,  Haas H and Langguth P. (2020 ) Investigation of pH-Responsiveness Inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X-ray Scattering. Langmuir 36(44):13331-13341. PDF
  3. Nogueira S, Schlegel A, Maxeiner K, Weber B, Barz M, Schroer M.A., Blanchet C.E, Svergun D, Ramishetti R, Peer D, Langguth P, Sahin U, and Haas H. (2020) Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery. ACS Applied Nano Materials. 11:10634-10635. PDF
  4. Kon E, Hazan-Halevy I, Rosenblum D, Cohen N, Chatterjee S, Veiga N, Raanani P, Bairey O, Benjamini O, Nagler A, Peer D. (2020) Resveratrol Enhances mRNA and siRNA Lipid Nanoparticles Primary CLL Cell Transfection. Pharmaceutics 12(6):E520.  PDF
  5. Van de Vyver T, Bogaert B, De Backer L, Joris F, Guagliardo R, Van Hoeck J, Merckx P, Van Calenbergh S, Ramishetti S, Peer D, Remaut K, De Smedt SC, and Raemdonck K (2020) Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner. ACS Nano. 14(4):4774-4791. PDF
  6. Ramishetti S, Hazan-Halevy I, Palakuri R, Chatterjee S, Naidu Gonna S, Dammes N, Freilich I, Kolik Shmuel L, Danino D, and Peer D (2020) A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes. Adv Mater. 30:e1906128. PDF
  7. Singh MS, Goldsmith M, Thakur K, Chatterjee S, Landesman-Milo D, Levy T, Kunz-Schughart LA, Barenholz Y, and Peer D. (2020) An Ovarian Spheroid Based Tumor Model that Represents Vascularized Tumors and Enables the Investigation of Nanomedicine Therapeutics. Nanoscale 23;12(3):1894-1903. PDF
  8. Veiga N, Goldsmith M, Diesendruck Y, Ramishetti S, Rosenblum D, Elinav E, Behlke MA, Benhar I, and Peer D. (2019) Leukocyte-Specific siRNA Delivery Revealing IRF8 as a Potential Anti-Inflammatory Target. J Control Release.  313:33-41.  PDF
  9. Gao M, Deng J, Liu F, Fan A, Wang Y, Wu H, Ding D, Kong D, Wang Z, Peer D, and Zhao Y. (2019) Triggered Ferroptotic Polymer Micelles for Reversing Multidrug Resistance to Chemotherapy. Biomaterials. 223:119486. PDF
  10. Hazan-Halevy I, Rosenblum D, Ramishetti S, and Peer D (2019) Systemic Modulation of Lymphocyte Subsets Using siRNAs Delivered via Targeted Lipid Nanoparticles. Methods Mol Biol. 1974:151-159. PDF
  11. Lusi V, Moore TL, Laurino F, Coclite A, Perreira R, Ferreira M1, Rizzuti I, Palomba R, Zunino P, Duocastella M4, Mizrahy S, Peer D, Decuzzi P (2019) A Tissue Chamber Chip for Assessing Nanoparticle Mobility in the Extravascular Space. Biomed Microdevices. 21(2):41. PDF
  12. Edri R, Gal I, Noor N, Harel T, Fleischer S, Adadi N, Green O, Shabat D, Heller L, Shapira A, Gat-Viks I, Peer D, and Dvir T. (2019) Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants. Adv Mater. 31(1):e1803895. PDF 

 2017-2018

  1. Liu G, Deng J, Liu F,  Wang Z, Peer  D and  Zhao Y. (2018) Hierarchical Theranostic Nanomedicine: MRI Contrast Agents as a Physical Vehicle Anchor for High Drug Loading and Triggered on-demand Delivery. J. Mat. Chem. B 6:1995–2003.  PDF
  2. Veiga N, Goldsmith M, Granot Y, Rosenblum D, Dammes N, Kedmi R, Ramishetti S, and Peer D (2018) Cell-Specific Delivery of Modified mRNA Expressing Therapeutic Proteins to Leukocytes. Nat Commun. 9(1):4493-449. PDF
  3. Goldsmith M,  Abramovitz L, Braunstein H, Horowitz M, and Peer D (2018) Quantitative Analysis of Recombinant Glucocerebrosidase Brain Delivery via Lipid Nanoparticles. Nano Futures 2(4). PDF
  4. Kedmi R*, Veiga N*, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N, Hazan-Halevy I,  Nahary L,  Leviatan-Ben-Arye S, Harlev M, Behlke M, Benhar I, Lieberman J, and Peer D (2018) A Modular Platform for Targeted RNAi Therapeutics. Nature Nanotechnology 13(3):214-219.  *denotes equal contribution PDF
  5. Karp J. M. and Peer D. (2018) Editorial: Focus on RNA interference: from nanoformulations to in vivo delivery. Nanotechnology 29(1):010201. PDF
  6. Zyuzin MV, Díez P, Goldsmith M, Carregal-Romero S, Teodosio C, Rejman J, FeliuN, Escudero A, Almendral MJ, Linne U, Peer D, Fuentes M, and Parak WJ (2017). Comprehensive and Systematic Analysis of the Immunocompatibility of Polyelectrolyte Capsules. Bioconjug Chem. PDF

 2015-2016

  1. Soffer-Tsur N., Peer D., and Dvir T (2016)  ECM-based Macroporous Sponges Release Essential Factors to Support the Growth of Hematopoietic Cells. Journal of Controlled Release 257:84-90. PDF
  2. Kedmi R, and Peer D. (2016) Zooming in on Selectins in Cancer. Sci. Transl. Med.  8(345):1-2. PDF
  3. Weinstein S,  Toker, IA, Emmanuel R, Ramishetti R, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abrahamc A, Benjamini B, Bairey O, Raanani R, Nagler A, Liebermane J and Peer D (2016) Harnessing RNAi Based-Nanomedicines for Therapeutic Gene Silencing in B cell Malignancies.  Proc. Natl. Acad. Sci. USA 113(1) E16-E22. PDF
  4. Dearling, J, Daka, A, Veiga, N, Peer, D, and Packard A (2016) ImmunoPET of Colitis: Defining Target Cell Populations and Optimizing Pharmacokinetics. Inflammatory Bowel Diseases 22(3):529-538. PDF
  5. Ben-Arye T., Park S., Shemesh J., Peer D., Levenberg S. and Yossifon G (2015) Dielectrophoretic Characterization of Cells in a Stationary Nanoliter Droplet Array with Generated Chemical gradients. Biomed Microdevices 17: 91. PDF
  6. Ramishetti S*, Kedmi R*, Goldsmith M, Leonard F, Speague AG, Godin B, Gozin M, Cullis P, Dykxhoorn DM, and Peer D (2015) Systemic Gene Silencing in Primary T lymphocytes using Targeted Lipid Nanoparticles. ACS Nano 9(7):6706-6716 *denotes equal contribution. PDF
  7. Yang D, Zeng T, Yang Y, Wang X, Hu J, Song Y, Chen L, Peer D, Wang X, and Bai C (2015) Specific Serum Chemokines Network Correlates Chemotherapy in Non-small-cell Lung Cancer. Cancer Letters. 365(1):57-67. PDF
  8. Hazan-Halevy I*, Rosenblum D*,Weinstein S, Bairey O, Raanani P,  and Peer D (2015) Cell-specific Uptake of Mantle Cell Lymphoma-Derived Exosomes by Malignant and Non-Malignant B-Lymphocytes. Cancer Letters. 364(1), 59-69. *denotes equal contribution. PDF
  9. Sigal N, Kaplan Zeevi M, Weinstein S, Peer D and Herskovits AA (2015). The Human P-glycoprotein Transporter enhances Type I Interferon Response to L. monocytogenes Infection. Infection and Immunity. 83(6):2358-2368. PDF
  10. Jacoby G*, Cohen K*, Tamon I, and Peer D*. and Back-Barkai R* (2015) Metastability in lipid-Based Particles Exhibits Temporally Deterministic and Controllable Behavior. Scientific Reports 5, 9481, 1-7.*denotes equal contribution. PDF
  11. Cao Y, Gao M, Chen C., Fan A. Zhang J, Kong D, Wang Z, Peer, D and Zhao, Y (2015) Triggered-Release Polymeric Conjugate Micelles for on-Demand Intracellular Drug Delivery. Nanotechnology 26:1-9. PDF
  12. Cohen ZR*, Ramishetti S*, Peshes-Yaloz N*, Goldsmith M, Wohl A, Zibly Z, and Peer D (2015). Localized RNAi Therapeutics of Chemo-Resistant Grade IV Glioma using Hyaluronan-Grafted Lipid-Based Nanoparticles. ACS Nano. 9(2):1581-1591.*denotes equal contribution,  PDF
  13. Perevedentseva E, Peer D, Uvarov V, Zousman B, and Levinson O (2015) Nanodiamonds of Laser Synthesis for Biomedical Applications. J. Nanosci. Nanotech. 15(2):1045-1052.PDF

2013-2014

  1. Drinberg V, Bitcover R, Rajchenbach W, and Peer D (2014) Modulating Cancer Multidrug Resistance by Sertraline in Combination with a Nanomedicine. Cancer Letters 354:290-298. PDF
  2. Soffer-Tsur N, Shevach M, Shapira A, Peer D, and Dvir T (2014) Optimizing the Biofabrication Process of Momentum-Based Scaffolds for Engineering Autologous Tissues. Biofabrication 6. PDF
  3. Amar-Lewis E, Azagury A, Goldbart R, Traitel T, Prestwood J, Landesman-Milo D, Peer D, and Kost J. (2014) Quaternized Starch-based Carrier for siRNA Delivery: from Cellular Uptake to Gene Silencing. Journal of Controlled Release 185:118-120. PDF
  4. Cohen K, Emmanuel R, Kisin-Finfer E, Shabat D, and Peer, D. (2014) Modulation of Drug Resistance in Ovarian Adenocarcinoma using Chemotherapy Entrapped in Hyaluronan-Grafted Nanoparticle Clusters. ACS Nano 8(3), 2185-2193. PDF
  5. Mizrahy S, Goldsmith M, Leviatan-Ben-Arye S, Kisin-Finfer E, Redy O, Srinivasan S, Shabat D, Godin B, and Peer D. (2014) Tumor Targeting Profiling of Hyaluronan-Coated Lipid Based-Nanoparticles. Nanoscale 6, 3742-3752. PDF
  6. Amram S, Ganoth A, Tichon O, Peer D, Nachliel E, Gutman M, and Tsfadia Y (2014) Structural Characterization of the Drug Translocation Path of MRP1/ABCC1. Israeli Journal of Chemistry 54:1382-1393. PDF
  7. Peer D, and Howard KA (2014). RNA Interference-based Therapeutics and Diagnostics. Drug Delivery and Translation Research 4:1-2. PDF
  8. Landesman-Milo D, and Peer D (2014) Toxicity Profiling of Several Common RNAi-based Nanomedicines: A Comparative Study. Drug Delivery and Translational Research  (1):96-103. PDF
  9. Wang X., Peer D., and Petersen B (2013) Molecular and Cellular Therapies: New Challenges and Opportunities. Molecular and Cellular Therapies 1:1-4.  PDF
  10. Dahan L, Huang L, Kedmi R, Behlke MA, and Peer D (2013) SNP Detection in mRNA in Living Cells Using Allele-Specific FRET Probes. PLoS ONE 8(9): e72389. PDF
  11. Dvash R, Khatchatouriants A, Solmesky LJ, Wibroe PP, Weil M, Moghimi SM, and Peer D (2013) Structural Profiling and Biological Performance of Phospholipid-Hyaluronan Functionalized Single-Walled Carbon Nanotubes. Journal of Controlled Released 170:295-305. PDF
  12. Emmanuel R, Weinstein S, Landesman-Milo D, and Peer D (2013) eiF3c: A Potential Therapeutic Target for Cancer. Cancer Letters 336:158-166. PDF
  13. Elinav E, and Peer D. (2013) Harnessing Nanomedicine for Mucosal Theranostics-A Silver Bullet at Last? ACS Nano. 7(4):2883-2890. PDF
  14. Landesman-Milo D, Goldsmith M, Arie SL, Witenberg B, Brown E,  Leibovitch S, Azriel S, Tabak S, Morad V, and Peer D (2013) Hyaluronan Grafted Lipid-Based Nanoparticles as RNAi Carriers for Cancer Cells. Cancer Letters 334:221-227. PDF

2010-2012

  1. Weinstein S, Emmanuel R, Jacobi AM, Abraham A, Behlke MA, Sprague AG, Novobrantseva TI, Nagler A, and Peer D (2012) RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma. PLoS One 7(8):e43343. PDF
  2. Moyano D, Goldsmith M, Solfiell D, Landesman-Milo D, Miranda O, Peer D,* and Rotello VM* (2012). Hydrophobicity Dictates Immune Response. Journal of American Chemical Society 134(9):3965-3967. *denotes equal contribution. PDF
  3. Ben-Arie N, Kedmi R, and Peer D (2012). Integrin-Targeted Nanoparticles for siRNA Delivery. Methods in Molecular.757:497-507. PDF
  4. Srinivasan C, Peer D, and Shimaoka M (2012). Integrin Targeted Stabilized Nanoparticles for an Efficient Delivery of siRNAs in vitro and in vivo. Methods in Molecular Biology 820:105-116. PDF
  5. Breiner-Goldstein E, Evron Z, Frenkel M, Cohen K, Nir Meiron K, Peer D, Roichman Y, Flescher E, and Fridman M (2011) Targeting Anthracycline-Resistant Tumor Cells with Synthetic Aloe-emodin Glycosides. ACS Medicinal Chemistry Letters:528-531. PDF
  6. Solmesky LJ, Shuman M, Goldsmith M, Weil M, and Peer D (2011) Assessing Cellular Toxicities in Fibroblasts upon Exposure to Lipid-Based Nanoparticles: a High Content Analysis Approach. Nanotechnology 22(49):494016. PDF
  7. Moghimi SM, Peer D, and Langer R (2011) Reshaping the Future of Nanopharmaceuticals: Ad ludicium. ACS Nano. 5(11):8454-8458. PDF
  8. Mizrahy S, Raz SR, Hasgaard M, Liu H, Soffer-Tsur N, Cohen K, Dvash R, Landsman-Milo D, Bremer MG, Moghimi SM, and Peer D (2011) Hyaluronan-Coated Nanoparticles: The Influence of the Molecular Weight on CD44-Hyaluronan Interactions and on the Immune Response. Journal of Controlled Release 156(2):231-238. PDF
  9. Bachar G, Cohen K, Hod R, Feinmesser R, Mizrachi A, Shpitzer T, Katz O, and Peer D (2011) Hyaluronan-Grafted Particle Clusters loaded with Mitomycin C as Selective Nanovectors for Primary Head and Neck Cancers. Biomaterials 32(21):4840-4848. PDF
  10. Kim SS, Subramanya S, Peer D, Shimaoka M, and Shankar P (2011) Antibody-Mediated Delivery of siRNAs for anti-HIV Therapy. Methods Mol. Biol. 721:339-353. PDF
  11. Drug E, Landesman-Milo D, Belgorodsky B, Ermakov N, Frenkel-Pinter M, Fadeev L, Peer D, and Gozin M (2011) Enhanced Bioavailability of Polyaromatic Hydrocarbons in the Form of Mucin Complexes. Chemical research in toxicology 24(3), 314-320. PDF
  12. Cohen-Kupiec R, Weinstein S, Kantor G, Peer D, and Weil M (2010) IKAP/hELP1 Down-Regulation in Neuroblastoma Cells Causes Enhanced Cell Adhesion Mediated by Contactin Overexpression. Cell Adh. Migr. 4(4):541-550. PDF
  13. Rivkin I, Cohen K, Koffler J, Melichov D., Peer D*, and Margalit R* (2010) Paclitaxel-Clusters Coated with Hyaluronan as Selective Tumor-Targeted Nanovectors. Biomaterials 31:7106-7114. *denotes equal contribution. PDF
  14. Kedmi R*, Ben-Arie N*, and Peer D (2010). The Systemic Toxicity of Positively Charged Lipid Nanoparticles and the Role of Toll-like receptor 4 in Immune Activation. Biomaterials 31:6867-6875. *denotes equal contribution. PDF
  15. Dearling JLJ, Voss S, Dunning P, Park EJ, Fahey F, Treves T Solapino S., Shimaoka M, Packard AB, and Peer D (2010) Detection of Intestinal Inflammation by microPET Imaging Using a 64Cu-Labeled Anti-b7 Integrin Antibody. Inflammatory bowel diseases16(9):1458-1466. PDF
  16. Kim S-S*, Peer D*, Kumar P*, Subramanya S, Wu H, Asthana D, Habiro K, Yang Y-G, N. Manjunath, Shimaoka M and Shankar P (2010) RNAi-mediated CCR5 silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT mice. Molecular Therapy 18:370-376. * denotes equal contribution. PDF

2000-2009

  1. Argov M, Kashi R, Peer D, and Margalit R (2009) Treatment of Resistant Human Colon Cancer Xenografts by a Fluoxetine-Doxorubicin Combination Enhances Therapeutic Responses Comparable to an Aggressive Bevacizumab Regimen. Cancer Letters 274(1):118-125. PDF
  2. Imai Y, Park EJ, Peer D, Peixoto A, Cheng G, von Andrian UH, Carman CV, and Shimaoka M (2008) Genetic Perturbation of the Putative Cytoplasmic Membrane-Proximal Salt Bridge Aberrantly Activates alpha(4) Integrins. Blood 112(13):5007-5015. PDF
  3. Peer D, Park EJ, Morishita Y, Carman CV, and Shimaoka M (2008) Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammation Target. Science 319:627-630. PDF
  4. Peer D, Zhu P, Carman CV, Lieberman J, and Shimaoka M (2007) Selective Gene Silencing in Activated Leukocytes by Targeting siRNAs to the Integrin Lymphocyte Function-Associated Antigen-1. Proc. Natl. Acad. Sci. USA, 104:4095-4100. PDF
  5. Shimaoka M, Kim M, Cohen EH, Yang W, Astrof N, Peer D, Salas A, Ferrand A, and Springer TA. (2006) AL-57, a Ligand-Mimetic Antibody to Integrin LFA-1, Reveals Chemokine-Induced Affinity Up-Regulation in Lymphocytes. Proc. Natl. Acad. Sci. USA 103(38):13991-13996. PDF
  6. Peer D, Dekel Y, Melikhov D, and Margalit R (2004) Fluoxetine Inhibits MDR Extrusion Pumps and Enhances Therapeutic responses to Chemotherapy in Syngeneic and Human Xenograft Mouse Tumor Models. Cancer Research 64:7562-7569. PDF
  7. Peer D, and Margalit R (2004) Tumor-Targeted Hyaluronan Nanoliposomes Increase the Antitumor Activity of Liposomal Doxorubicin in a Syngeneic and Human Xenografts Mouse Tumor. Neoplasia 6:343-353. PDF
  8. Peer D, and Margalit R (2004)  Loading Mitomycin C Inside Long-Circulating Hyaluronan Targeted Nano-Liposomes Increases its Antitumor Activity in Three Mice Tumor Models. Int. Journal of Cancer 108(5):780-789. PDF
  9. Peer D, Florentin A, and Margalit R. (2003) Hyaluronan is a Key Component in Cryoprotection and Formulation of Targeted Unilamellar Liposomes. Biochim Biophys. Acta. 1612(1):76-82. PDF
  10. Peer D, and Margalit R (2000) Physicochemical Evaluation of a Stability-Driven Approach to Drug Entrapment in Regular and  Surface-Modified Liposomes. Arch. Biochem. Biophys. 383:185–190. PDF
REVIEWS

2023-2024

  1. Tarab-Ravski D, Stotsky-Oterin L, Elisha A, Kundoor GR, Ramishetti S, Hazan-Halevy I, Haas H, Peer D (2024) The future of genetic medicines delivered via targeted lipid nanoparticles to leukocytes. J Control Release. 376:286-302. PDF
  2. Masarwy R, Stotsky-Oterin L, Elisha A,  Hazan-Halevy I, Peer D (2024) Delivery of Nucleic Acid Based Genome Editing Platforms via Lipid Nanoparticles: Clinical Applications. ADDR 211(115359) 1-21. PDF
  3. Qassem S, Breier D, Naidu G.S, Hazan-Halevy I, Peer D (2024) Unlocking the Therapeutic Potential of Locked Nucleic Acids Through lipid Nanoparticle Delivery. Molecular Therapy: Nucleic Acids 35, 1-12. PDF 
  4. Chatterjee S, Edo Kon, Sharma P,  Peer D (2024) Endosomal escape: A bottleneck for LNP-mediated therapeutics. PNAS 121(11) e2307800120. PDF
  5. Sharma P, Hoorn D, Aitha A,  Breier D, Peer D (2024) The Immunostimulatory Nature of mRNA-lipid Nanoparticles. ADDR 205(115175):1-22. PDF
  6. Kon E, Ad-El N, Hazan-Halevy I, Stotsky-Oterin L, Peer D (2023) Targeting Cancer with mRNA-Lipid Nanoparticles: Key Considerations and Future Prospects. Nat Rev Clin Oncol. 20(11):739-754. PDF
  7. Rampado R, Peer D. (2023) Design of Experiments in the Optimization of Nanoparticle-Based Drug Delivery Systems. J Control Release .358 398–419. PDF
  8. Hazan-Halevy I, Kon E, Stotsky-Oterin L, Peer D (2023) mRNA Vaccines: Using Tiny Particles to Fight Viruses. Frontiers for Young Minds. PDF
  9. Veiga N, Diesendruck Y, Peer D (2023) Targeted Nanomedicine: Lessons Learned and Future Directions. J Control Release S0168-3659. PDF
  10. Breier D, Peer D (2023) Genome Editing in Cancer: Challenges and Potential Opportunities. Bioactive Material 21: 394-402. PDF :   

2021-2022

  1. Huang X, Kon E, Han X, Zhang X, Kong N, Mitchell MJ, Peer D, Tao W. (2022) Nanotechnology-Based Strategies Against SARS-CoV-2 Variants. Nat Nanotechnol. PDF
  2. Tarab-Ravski D, Stotsky-Oterin L, Peer D. (2022) Delivery Strategies of RNA Therapeutics to Leukocytes. J. Control. Release. 342: 362-371. PDF
  3. Gutkin A, Rosenblum D and Peer D. (2021) RNA Delivery with a Human Virus-Like Particle. Nature Biotechnology. PDF 
  4. Kon E, Elia U, Peer D (2022) Principles of Designing an Optimal mRNA Lipid Nanoparticle Vccine. Current Opinion in Biotechnology 73: 1-8. PDF
  5. Schlich M, Palomba R,  Costabile G, Mizrahy S, Pannuzzo M, Peer D, Decuzzi P (2021) Cytosolic Delivery of Nucleic Acids: The Case of Ionizable Lipid Nanoparticles. Bioenjeenering and Translational Medicine 6(2):e10213. PDF
  6. Decuzzi P, Peer D, Mascolo DD, Palange AL, Manghnani PN, Moghimi SM, Farhangrazi ZS, Howard KA, Rosenblum D, Liang T, Chen Z, Wang Z, Zhu JJ, Gu Z, Korin N, Letourneur D, Chauvierre C, van der Meel R, Kiessling F, Lammers T. (2021) Roadmap on Nanomedicine. Nanotechnology 32(1):012001. PDF

2019-2020

  1. Dammes N, Peer D (2020) Paving the Road for RNA Therapeutics. Trends in Pharmacological Sciences 41(10):755-775. PDF
  2. Rosenblum D, Gutkin A, Dammes N,  Peer D (2020) Progress and Challenges Towards CRISPR/Cas Clinical Translation. Adv Drug Deliv Rev. S0169(20): 30080-30086. PDF
  3. Veiga N,  Diesendruck Y, and Peer D (2020) Targeted Lipid Nanoparticles for RNA Therapeutics and Immunomodulation in leukocytes. Adv Drug Deliv Rev. S0169(20): 30022-30033. PDF
  4. Dammes N, and Peer D (2020) Monoclonal Antibody-Based Molecular Imaging Strategies and Theranostic Opportunities. Theranostics. 10(2):938-955. PDF
  5. Moghimi SM, and Peer D (2019) Reprogramming the Lymphocyte Axis for Immunotherapy. Advanced Drug Delivery Reviews 141:1–2. PDF
  6. Dhyani M, Joshi N, Bemelman WA, Gee MS, Yajnik V, D’Hoore A, Traverso G, Donowitz M, Mostoslavsky G, Lu TK, Lineberry N, Niessen HG, Peer D, Braun J, Delaney CP, Dubinsky MC, Guillory AN, Pereira M, Shtraizent N, Honig G, Polk DB, Hurtado-Lorenzo A, Karp JM, and Michelassi F (2019) Challenges in IBD Research: Novel Technologies. Inflamm Bowel Dis. 25:S24-S30. PDF
  7. Granot-Matok Y,  Kon E, Dammes N, Mechtinger G, and Peer D (2019) Therapeutic mRNA Delivery to Leukocytes. Journal of Controlled Release 305, 165-175. PDF
  8. Mizrahy S, Gutkin A, Decuzzi P, and Peer D (2019) Targeting Central Nervous System Pathologies with Nanomedicines. J. Drug Target. 27(5-6):542-554. PDF

 2017-2018

  1. Ramishetti S, and Peer D (2018) Engineering Lymphocytes with RNAi. Adv Drug Deliv Rev. 141:55-66.  PDF
  2. Gutkin A, and Peer D (2018) Gene Silencing in the Right Place at the Right Time. Mol Ther. 5;26(12):2875.  PDF
  3. Rosenblum D, Joshi N, Tao W, Karp J.M,  and Peer D (2018) Progress and Challenges Towards Targeted Delivery of Cancer Therapeutics. Nature Communications 9:1-12. PDF
  4. Granot Y,  and Peer D (2017) Delivering the Right Message: Challenges and Opportunities in Lipid Nanoparticles-Mediated Modified mRNA Therapeutics- An Innate Immune System Standpoint. Semin Immunol 34:68-77. PDF
  5. Rietwyk S, and Peer D (2017) Next-Generation Lipids in RNA Interference Therapeutics. ACS Nano 11:7572−7586. PDF
  6. Alvarez MM, Aizenberg J, Analoui M, Andrews AM, Bisker G, Boyden ES, Kamm R.D, Karp JM, Mooney DJ, Oklu R, Peer D, Stolzoff M,  Strano MS, Trujillo-de Santiago G, Webster TJ, Weiss PS, and Khademhosseini A (2017) Emerging Trends in Micro- and Nanoscale Technologies in Medicine: from Basic Discoveries to Translation. ACS Nano 11:5195-5214. PDF
  7. Mizrahy S, Hazan-Halevy I, Dammes N, Landesman-Milo D, and Peer D (2017) Current Progress in Non-viral RNAi-Based Delivery Strategies to Lymphocytes. Molecular Therapy 25:1491-1500. PDF
  8. Mizrahy S, Hazan-Halevy I, Landesman-Milo D,  and  Peer D (2017) Advanced strategies in Immune Modulation of Cancer using Lipid-Based Nanoparticles. Frontiers in Immunology 8:69. PDF
  9. Anchordoquy TJ,  Barenholz Y,  Boraschi D, Chorny M,  Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS,  Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, Moghimi SM, Pagliaro L,  Park JH,  Peer D, Ruoslahti E, Serkova NJ, and Simber D (2017) Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions. ASC Nano.  PDF
  10. Ng BD, and Peer D (2017) Orchestrating a Symphony on a Single Conjugate: Aptamer Targeting, Gene Silencing, and Immunomodulation to Enhance Antitumor Response. Molecular Therapy 25:5-7. PD

2015-2016

  1. Hazan-Halevy I, Landesman-Milo D, Rosenblum D, Mizrahy S, Ng BD, and Peer D (2016) Immunomodulation of Hematological Malignancies using Oligonucleotides Based-Nanomedicines. Journal of Controlled Release, 244:149-156. PDF
  2. Gutkin A, Cohen ZR, and Peer D (2016) Harnessing Nanomedicine for Therapeutic Intervention in Glioblastoma. Expert Opinion on Drug Delivery ISSN: 1744-7593:1573-1582. PDF
  3. Ramishetti S, Landesman-Milo D, and Peer D (2016) Advances in RNAi Therapeutic Delivery to Leukocytes Using Lipid Nanoparticles. J Drug Target. 24(9):780-786. PDF
  4. Singh MS, and Peer D (2016) siRNA Delivery: Current Trends and Future Perspectives.  Ther Deliv. 51-53. PDF
  5. Singh MS, Peer D (2016) RNA Nanomedicines: the Next Generation of Drugs? Current Opinion in Biotechnology 28-34. PDF
  6. Landesman-Milo D, and Peer D (2016) Transforming Nanomedicines from Lab-Scale Production to Novel Clinical Modality. Bioconjug Chem. 27(4):855-862. PDF
  7. Moyano DF, Liu Y., Peer D and Rotello VM (2016) Modulation of immune response using engineered nanoparticle surfaces. Small 12(1),76-82. PDF
  8. Moghimi SM, Hunter AC, and Peer D (2016) Platelet Mimicry: The emperor’s New Clothes? Nanomedicine 12:245-248. PDF
  9. Landesman-Milo D, Ramishetti S, and Peer D (2015) Nanomedicine as an Emerging Platform for Metastatic Lung Cancer Therapy. Cancer and Metastasis Reviews 34(2):291-301. PDF
  10. Ganoth A, Cohen K.M, and Peer D (2015) Overcoming Multidrug Resistance with Drug Delivery Strategies. Expert Opin Drug Deliv.  12(2):223-238. PDF

2013-2014

  1. Peer D (2014) Precision medicine – delivering the goods? Cancer Letters 352:2-3. PDF
  2. Goldsmith M, Abramovitz L, and Peer D (2014) Precision Nanomedicine in Neurodegenerative Diseases. ACS Nano 8(3):1958-1965. PDF
  3. Bogart K., Pourroy G, Murphy CJ, Puntes VF, Pellegrino T, Rosenblum D, Peer D*, and Lévy R* (2014) Nanoparticles for Imaging, Sensing, and Therapeutic Intervention. ACS Nano 8(4):3107–3122. *denotes equal contribution. PDF
  4. Peer D (2014) Harnessing RNAi Nanomedicine for Precision Therapy. Molecular and Cellular Therapies 2(5):2-11.PDF
  5. Rosenblum D, and Peer D (2014) Omics-Based Nanomedicine: The Future of Personalized Oncology. Cancer Letters. 352, 126-136. PDF
  6. Peer D, Giannechi N. and Luo D (2013) Nanoparticles in Biology. Journal of Materials Chemistry . PDF
  7. Mizrahy S, Landesman-Milo D, and Peer D (2013) Sweet Fairytale: Carbohydrates as Backbones for Glyconanomedicine. Israel Journal of Chemistry 53 (9-10):616-629. PDF
  8. Howard KA. and Peer D (2013) Providing the Full Picture: a Mandate for Standardizing Nanoparticle-Based Drug Delivery.Nanomedicine (Lond). 8(7):1031-1033. PDF
  9. Peer D (2013) A Daunting Task: Manipulating Leukocyte Function with RNAi. Immunol Rev. 253:185–197. PDF

2006-2012

  1. Vorup-Jensen T, and Peer D (2012) Nanotoxicity and the Importance of Being Earnest. Adv. Drug Deliv. Rev. 64 (15):1661-1662.PDF
  2. Daka A, and Peer D (2012) RNAi-Based Nanomedicines for Targeted Personalized Therapy. Adv. Drug Deliv. Rev. 64(13), 1508-1521. PDF
  3. Peer D (2012) Immunotoxicity Derived from Manipulating Leukocytes with Lipid-based Nanoparticles. Adv. Drug Deliv. Rev. 64 (15):1738–1748. PDF
  4. Barenholz Y, and Peer D (2012) Liposomes, lipid Biophysics, and Sphingolipid Research: from Basic to Translational Research. Chemistry & Physics of Lipids 165:363-364. PDF
  5. Barenholz Y, and Peer D (2012) Liposomes and other Assemblies as Drugs and Nano-Drugs: from basic and Translational Research to the Clinics. Journal of Controlled Release 160(2):115-116. PDF
  6. Landsman–Milo D, and Peer D (2012) Altering the Immune Response with liposomes. Journal of Controlled Release 161:600-608. PDF
  7. Mizrahy S, and Peer D (2012). Polysaccharides as Building Blocks for Nanotherapeutics. Chem. Soc. Rev. 41:2623–2640. PDF
  8. Goldsmith M, Mizrahy S, and Peer D (2011) Grand Challenges in Modulating the Immune Response with RNAi Nanomedicines. Nanomedicine 6(10):1771-1785. PDF
  9. Peer D, and Lieberman J (2011) Special Delivery: Targeted Therapy with Small RNAs. Gene therapy 18(12):1127-1133. PDF
  10. Elfakess R, and Peer D (2010) Overcoming RNAi Transduction in Leukocytes using Targeted and Stabilized Nanoparticles. IDrugs 13(9):626-631. PDF
  11. Weinstein S, and Peer D (2010) RNAi Nanomedicines: Challenges and within Opportunities the Immune System. Nanotechnology 21(23), 232001:1-13. PDF
  12. Peer D (2010) Induction of Therapeutic Gene Silencing in Leukocyte-Implicated Diseases by Targeted and Stabilized Nanoparticles: a mini-review. Journal of Controlled Release. 148(1):63-68. PDF
  13. Kedmi R, and Peer D (2009) RNAi Nanoparticles in the Service of Personalized Medicine. Nanomedicine 4(8):853-855. PDF
  14. Peer D, and Shimaoka M (2009) Systemic siRNA Delivery to Leukocyte-Implicated Diseases. Cell Cycle 8:853-859. PDF
  15. Peer D, Karp JM, Hong S, Farokhzad O, Margalit R, and Langer R (2007) Nanocarriers as an Emerging Platform for Cancer Therapy. Nature Nanotechnology 2:751-760. PDF
  16. Klausner EA, Peer D, Chapman RL, Multack RF, and Andurkar SV. (2007) Corneal Gene Therapy. Journal of Controlled Release 124(3):107-133. PDF
  17. Peer D, and Margalit R (2006) Fluoxetine and Reversal of Multidrug Resistance. Cancer Letters 237:180-187. PDF
BOOKS
  1. Peer D (2021) Handbook of Harnessing Biomaterials in Nanomedicine: Preparation, Toxicity, and Applications. 2nd edition Pan Stanford Publishing.
  2. Howard KA, Jensen T, Peer D  (2016) Nanomedicine. Springer Publishing.
  3. Peer D  (2013) Nanotechnology for Delivery of Therapeutic Nucleic Acids. Pan Stanford Publishing.
  4. Peer D (2012) Handbook of Harnessing Biomaterials in Nanomedicine: Preparation, Toxicity, and Applications. Pan Stanford Publishing.
COMMENTARIES
  1. Dolgin E. (2022) Better Lpids to Power Next Generation of mRNA Vaccines. Science 376:680-681. PDF
  2. Akhtar A. (2021) Capturing the Perfect Pose. Communication Biology 4:10741-2. PDF
  3. Sarmento B, WeintrauDas Neves J,  Santos HA,  Santos L, MitragotriS, Little S,  Peer D, Amiji  MM, and Alonso MJ (2019) On the Issue of Transparency and Reproducibility in Nanomedicine. Nature Nanotechnology 14:629–635. PDF
  4. Weintraub K (2013) The New Gold StandaKrd. Nature 495:S14-S16. PDF
  5. MacLachlan I (2008) siRNAs with Guts. Nature Biotechnology 26:403–405. PDF
  6. Mullard A (2008) Escorting siRNA. Nature Reviews Molecular Cell Biology 9, 189. PDF
  7. Szoka F (2008) The Art of Assembly. Science 319 (5863):578-579. PDF
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Prof. Dan Peer
Laboratory of NanoMedicine

Mailing Address: Department of Cell Research and Immunology, Tel-Aviv University, Ramat Aviv, Tel-Aviv, 69978 Israel

Office Address: Britannia Building, office 226 Tel: 972-3-640-5926 Fax: 972-3-640-5926

Labs: 
(1) Britannia Building, room 226
(2) Center of Nanotechnology and Nanoscience, room 27

Tel: 972-3-640-7925 (Britannia lab)
Tel: 972-3-640-5600 (Nano lab)

Menu
Menu
Menu
Contact us

Prof. Dan Peer
Laboratory of NanoMedicine

Mailing Address: Department of Cell Research and Immunology, Tel-Aviv University, Ramat Aviv, Tel-Aviv, 69978 Israel

Office Address: Britannia Building, office 226 Tel: 972-3-640-5926 Fax: 972-3-640-5926

Labs: 
(1) Britannia Building, room 226
(2) Center of Nanotechnology and Nanoscience, room 27

Tel: 972-3-640-7925 (Britannia lab)
Tel: 972-3-640-5600 (Nano lab)

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