CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy
Ranit Kedmi*, Nuphar Veiga*, Srinivas Ramishetti, Meir Goldsmith, Daniel Rosenblum,
Niels Dammes, Inbal Hazan-Halevy, Limor Nahary, Shani Leviatan-Ben-Arye, Michael Harlev,
Mark Behlke, Itai Benhar, Judy Lieberman and Dan Peer
Progress and challenges towards targeted delivery of cancer therapeutics
Rosenblum D, Joshi N, Tao W, Karp JM and Peer D Nat Commun (2018) 9;1410, 1-12 Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, only 15 passively targeted nanocarriers (NCs) have been approved for clinical use and none […]
Special delivery: targeted therapy with small RNAs
Peer D, Lieberman J Gene Ther (2011) 18(12):1127-1133. Harnessing RNA interference using small RNA-based drugs has great potential to develop drugs designed to knock down expression of any disease-causing gene, thereby greatly expanding the universe of possible drug targets. However, delivering small RNAs into specific tissues and cells is still a hurdle. Here, we review recent […]
Polysaccharides as building blocks for nanotherapeutics
Mizrahy S and Peer D Chem Soc Rev. (2012), 41(7):2623-2640. The use of polysaccharides as building blocks in the development of nano-sized drug delivery systems is rapidly growing. This can be attributed to the outstanding virtues of polysaccharides such as biocompatibility, biodegradability, low toxicity and low cost. In addition, the variety of physicochemical properties and the ease of chemical modifications enable […]
Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles
Srinivas Ramishetti*, Ranit Kedmi*, Meir Goldsmith, Fransisca Leonard, Andrew G. Sprague, Biana Godin, Michael Gozin, Pieter R. Cullis, Derek M. Dykxhoorn, and Dan Peer
A modular platform for targeted RNAi therapeutics
Ranit Kedmi*, Nuphar Veiga*, Srinivas Ramishetti, Meir Goldsmith, Daniel Rosenblum,
Niels Dammes, Inbal Hazan-Halevy, Limor Nahary, Shani Leviatan-Ben-Arye, Michael Harlev,
Mark Behlke, Itai Benhar, Judy Lieberman and Dan Peer
Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
Nuphar Veiga, Meir Goldsmith, Yasmin Granot, Daniel Rosenblum, Niels Dammes, Ranit Kedmi, Srinivas Ramishetti & Dan Peer