Researches

We use a conformation-sensitive targeting strategy to achieve in vivo gene silencing in a selective subset of leukocytes and show potential therapeutic applications in a

Genome editing approaches such as CRISPR/Cas9 system is routinely used to permanently and precisely disrupt potentially any gene of interest. Yet the efficiency of gene

RNA vaccines work by introducing an mRNA sequence, which is coded for a disease-specific antigen. This antigen is recognized by the immune system and starts

We are harnessing RNA payloads (RNAi, mRNA, saRNA, and cirRNA)  as in vivo tools for drug discovery. Nucleic acids loaded lipid nanoparticles have emerged as a promising

This research was initiated in order to manipulate adult stem cells in vivo using nucleic acids-based targeted therapeutics

This research aims to develop novel nucleic acids-based therapeutics for hematological malignancies

The focus of this research is to design novel neurotrophic virus inspired nanotherapeutics to deliver nucleic acids into the CNS. We aim to utilize such therapeutic modality and develop new remedies for neurodevelopmental disorders.

We aspire to utilize oligonucleotides loaded LNPs for in vivo reprograming of leukocytes and thus to design novel immunomodulatory therapeutic approaches for autoimmune disorders and cancer.

The goal of this project is to explore resistance pathways of cancer cells and translate the acquired knowledge by designing novel RNAi-based nanotherapeutics.

We aim to utilize RNA-loaded lipid nanoparticles in order to design new therapeutic modalities for various malignancies, including head & neck cancer, glioblastoma and breast cancer.