ACS Nano 2020
Elia U, Ramishetti S, Rosenfeld R, Dammes N, Bar-Haim E, Somu Naidu G, Makdasi E, Yahalom-Ronen Y, Tamir H, Paran N, Cohen O, Peer D
In this study, we present the design of mRNA vaccine based on Lipid Nano Particles (LNPs)- encapsulated mRNA encoded for SARS-CoV-2 human Fc-conjugated receptor domain. Intramuscular injection elicits a robust humoral response, a high level of neutralizing antibodies, and a TH1-biased cellular response in BALBc mice. The data demonstrated the potential of our lipids as promising candidates for LNPs-based, RNA vaccines in general and for COVID-19 in particular.